Anti-Human HNRNPL Polyclonal Antibody (HB914014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HB914014

品牌

abinScience

描述

Anti-Human HNRNPL Polyclonal Antibody (HB914014) is a rabbit polyclonal antibody detecting HNRNPL in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human HNRNPL (Ser381-Ser589).

靶标

hnRNP L, HNRPL, Heterogeneous nuclear ribonucleoprotein L, HNRNPL

纯化方式

Purified by antigen affinity column.

Accession号

P14866

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Heterogeneous nuclear ribonucleoprotein L (HNRNPL) is a ~64 kDa protein. Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.

1. Kuninger, DT. et al. (2002) Nucleic acids research 30, 823-9. PMID: 11809897

2. Liu, G. et al. (2012) The Journal of biological chemistry 287, 22709-16. PMID: 22570490

3. Shankarling, G. et al. (2014) Molecular and cellular biology 34, 71-83. PMID: 24164894

4. Loh, TJ. et al. (2015) Biochimica et biophysica acta 1849, 743-50. PMID: 25623890

5. Blatter, M. et al. (2015) Journal of molecular biology 427, 3001-22. PMID: 26051023

6. Piñol-Roma, S. et al. (1989) The Journal of cell biology 109, 2575-87. PMID: 2687284

7. Hollensen, AK. et al. (2020) eLife 9. PMID: 33174841

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human HNRNPL Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human HNRNPL Polyclonal Antibody (HB914014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human HNRNPL Polyclonal Antibody (HB914014)

概述

图片

参考文献

产品说明书

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