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Anti-Human HNRNPL Polyclonal Antibody (ARO-A13423)

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概述
货号ARO-A13423
品牌ProteoGenix
描述
Anti-Human HNRNPL Polyclonal Antibody (ARO-A13423) is a rabbit polyclonal antibody detecting hnRNP L, HNRPL, Heterogeneous nuclear ribonucleoprotein L, HNRNPL in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human HNRNPL (Ser381-Ser589).
靶标hnRNP L, HNRPL, Heterogeneous nuclear ribonucleoprotein L, HNRNPL
纯化方式Purified by antigen affinity column.
Accession号P14866
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Heterogeneous nuclear ribonucleoprotein L (HNRNPL) is a ~64 kDa protein. Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.

1. Kuninger, DT. et al. (2002) Nucleic acids research 30, 823-9. PMID: 11809897
2. Liu, G. et al. (2012) The Journal of biological chemistry 287, 22709-16. PMID: 22570490
3. Shankarling, G. et al. (2014) Molecular and cellular biology 34, 71-83. PMID: 24164894
4. Loh, TJ. et al. (2015) Biochimica et biophysica acta 1849, 743-50. PMID: 25623890
5. Blatter, M. et al. (2015) Journal of molecular biology 427, 3001-22. PMID: 26051023
6. Piñol-Roma, S. et al. (1989) The Journal of cell biology 109, 2575-87. PMID: 2687284
7. Hollensen, AK. et al. (2020) eLife 9. PMID: 33174841
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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