Anti-CDK9 Polyclonal Antibody (HW357014)

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概述
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产品说明书

概述

货号

HW357014

品牌

abinScience

描述

Anti-CDK9 Polyclonal Antibody (HW357014) is a rabbit polyclonal antibody detecting CDK9 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CDK9 (Glu15-Ala340).

靶标

TAK, CDC2L4, C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Cyclin-dependent kinase 9, CDK9, Tat-associated kinase complex catalytic subunit

纯化方式

Purified by antigen affinity column.

Accession号

P50750

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Cyclin-dependent kinase 9 (CDK9) is a ~42 kDa protein. Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELFE. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g.

1. Fu, TJ. et al. (1999) The Journal of biological chemistry 274, 34527-30. PMID: 10574912

2. Ivanov, D. et al. (2000) Molecular and cellular biology 20, 2970-83. PMID: 10757782

3. Kim, JB. et al. (2001) The Journal of biological chemistry 276, 12317-23. PMID: 11145967

4. Lavoie, SB. et al. (2001) Journal of molecular biology 312, 675-85. PMID: 11575923

5. Bourgeois, CF. et al. (2002) Molecular and cellular biology 22, 1079-93. PMID: 11809800

6. Lin, X. et al. (2002) The Journal of biological chemistry 277, 16873-8. PMID: 11884399

7. Fujinaga, K. et al. (2004) Molecular and cellular biology 24, 787-95. PMID: 14701750

8. Jang, MK. et al. (2005) Molecular cell 19, 523-34. PMID: 16109376

9. Yang, Z. et al. (2005) Molecular cell 19, 535-45. PMID: 16109377

10. Yu, DS. et al. (2010) EMBO reports 11, 876-82. PMID: 20930849

Note

For research use only.

图片

参考文献

产品说明书

Anti-CDK9 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CDK9 Polyclonal Antibody (HW357014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CDK9 Polyclonal Antibody (HW357014)

概述

图片

参考文献

产品说明书

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