Anti-Human PIN1 Polyclonal Antibody (HC505014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC505014

品牌

abinScience

描述

Anti-Human PIN1 Polyclonal Antibody (HC505014) is a rabbit polyclonal antibody detecting PIN1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant Human PIN1 (Glu51-Glu163).

靶标

Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

纯化方式

Purified by antigen affinity column.

Accession号

Q13526

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a ~18 kDa protein. Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK.

1. Lee, TH. et al. (2011) Molecular cell 42, 147-59. PMID: 21497122

2. Steger, M. et al. (2013) Molecular cell 50, 333-43. PMID: 23623683

3. Nechama, M. et al. (2018) Nature communications 9, 1603. PMID: 29686383

4. Lim, JH. et al. (2011) The Journal of biological chemistry 286, 44403-11. PMID: 22033920

5. Yu, L. et al. (2006) The Journal of biological chemistry 281, 18201-7. PMID: 16644721

6. Dougherty, MK. et al. (2005) Molecular cell 17, 215-24. PMID: 15664191

7. Phan, RT. et al. (2007) Nature immunology 8, 1132-9. PMID: 17828269

8. Min, SH. et al. (2012) Molecular cell 46, 771-83. PMID: 22608923

10. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675

Note

For research use only.

图片

参考文献

产品说明书

Anti-Human PIN1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PIN1 Polyclonal Antibody (HC505014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human PIN1 Polyclonal Antibody (HC505014)

概述

图片

参考文献

产品说明书

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