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Anti-Human PIN1 Polyclonal Antibody (PTX20036)

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概述
货号PTX20036
品牌ProteoGenix
描述
Anti-Human PIN1 Polyclonal Antibody (PTX20036) is a rabbit polyclonal antibody detecting Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PIN1 (Glu51-Glu163).
靶标Rotamase Pin1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, PIN1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
纯化方式Purified by antigen affinity column.
Accession号Q13526
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) is a ~18 kDa protein. Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK.

1. Lee, TH. et al. (2011) Molecular cell 42, 147-59. PMID: 21497122
2. Steger, M. et al. (2013) Molecular cell 50, 333-43. PMID: 23623683
3. Nechama, M. et al. (2018) Nature communications 9, 1603. PMID: 29686383
4. Lim, JH. et al. (2011) The Journal of biological chemistry 286, 44403-11. PMID: 22033920
5. Yu, L. et al. (2006) The Journal of biological chemistry 281, 18201-7. PMID: 16644721
6. Dougherty, MK. et al. (2005) Molecular cell 17, 215-24. PMID: 15664191
7. Phan, RT. et al. (2007) Nature immunology 8, 1132-9. PMID: 17828269
8. Min, SH. et al. (2012) Molecular cell 46, 771-83. PMID: 22608923
10. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human PIN1 Polyclonal Antibody

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