| 背景 | CD9 antigen is a ~25 kDa protein. Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. 1. Le Naour, F. et al. (2000) Science (New York, N.Y.) 287, 319-21. PMID: 106347902. Miyado, K. et al. (2000) Science (New York, N.Y.) 287, 321-4. PMID: 106347914. Ishibashi, T. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 96-102. PMID: 147159425. Jégou, A. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 10946-51. PMID: 216903516. Charrin, S. et al. (2013) Nature communications 4, 1674. PMID: 235756787. Takeda, Y. et al. (2003) The Journal of cell biology 161, 945-56. PMID: 127964809. Takeda, Y. et al. (2008) The Journal of biological chemistry 283, 26089-97. PMID: 18662991 |
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