| 背景 | Leukocyte surface antigen CD47 (MER6) is a ~33 kDa protein. Adhesive protein that mediates cell-to-cell interactions. Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins. Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. Plays a role in modulating pulmonary endothelin EDN1 signaling. Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure. CD47 is the therapeutic target of magrolimab (clinical). 1. Bauer, EM. et al. (2010) Cardiovascular research 88, 471-81. PMID: 206104153. Rogers, NM. et al. (2017) Cardiovascular research 113, 15-29. PMID: 277426214. Manna, PP. et al. (2005) The Journal of biological chemistry 280, 29637-44. PMID: 159172386. Isenberg, JS. et al. (2008) Annals of surgery 247, 180-90. PMID: 181569397. Oldenborg, PA. et al. (2000) Science (New York, N.Y.) 288, 2051-4. PMID: 10856220 |
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