Endo-beta-N-acetylglucosaminidase EndoS (Endo S) is a ~111 kDa protein. Endoglucosidase that acts as a host immune evasion factor by mediating hydrolysis of the N-linked glycan from the Fc region of host immunoglobulin-gamma (IgG) during infection. Specifically catalyzes the hydrolysis of the beta-1,4 linkage between the first two N-acetylglucosamine residues of the complex-type N-linked glycan located on 'Asn-297' of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 or IGHG4), thereby preventing interaction between IgGs and Fc receptors and ability to activate the complement pathway. Shows a specificity for biantennary complex type N-glycans; does neither cleave larger complex type glycans nor oligomannose and nor hybrid-type glycans. Specifically acts on IgGs; does not act on immunoglobulin alpha, beta, delta or mu. 1. Collin, M. et al. (2001) The EMBO journal 20, 3046-55. PMID: 114065812. Collin, M. et al. (2001) Infection and immunity 69, 7187-9. PMID: 115981003. Collin, M. et al. (2002) Infection and immunity 70, 6646-51. PMID: 124383377. Goodfellow, JJ. et al. (2012) Journal of the American Chemical Society 134, 8030-3. PMID: 225511678. Huang, W. et al. (2012) Journal of the American Chemical Society 134, 12308-18. PMID: 227474149. Dixon, EV. et al. (2014) The Journal of biological chemistry 289, 13876-89. PMID: 2466880610. Trastoy, B. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 6714-9. PMID: 24753590 | 
