Anti-Mouse HMGB1 Recombinant Antibody (DPH1.1) (MY200013)

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规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

MY200013

abinScience

种属反应性

Bovine, Canine, Equine, Porcine

FCM, FuncS, IF, WB

IgG1, kappa

DPH1.1

High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P63158

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

产品使用信息

应用方法	稀释比例
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy.

1. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148

2. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706

3. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764

4. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472

5. Mitola, S. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 12-5. PMID: 16365390

For research use only.

SDS-PAGE

SDS-PAGE for Anti-Mouse HMGB1 Antibody (DPH1.1)
Western blot

Western blot analysis was performed using anti-HMGB1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human HMGB1 (Catalog No: HY200011)
Lane 2: negative control

产品说明书

Anti-Mouse HMGB1 Recombinant Antibody (DPH1.1).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse HMGB1 Recombinant Antibody (DPH1.1) (MY200013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse HMGB1 Recombinant Antibody (DPH1.1) (MY200013)

概述

图片

参考文献

产品说明书

相关产品推荐

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