Anti-Human Complement C6 Recombinant Antibody (SAA0492) (HY421013)

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50ug
100ug
1mg

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概述
图片
参考文献
产品说明书

概述

货号

HY421013

品牌

abinScience

描述

Anti-Human C6/Complement C6 Recombinant Antibody (SAA0492) (HY421013) is a mouse monoclonal antibody detecting Complement C6 in ELISA, SPR, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, SPR, WB

宿主

Mouse

克隆类型

Monoclonal

同种型

IgG2a, kappa

克隆号

SAA0492

靶标

Complement component C6, C6

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Protein A/G purified from cell culture supernatant.

Accession号

P13671

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

背景

Complement component C6 (Complement C6) is a ~104 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending.

1. Aleshin, AE. et al. (2012) The Journal of biological chemistry 287, 10210-10222. PMID: 22267737

2. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194

3. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837

4. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168

5. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328

6. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456

7. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human C6/Complement C6 Antibody (SAA0492)

参考文献

产品说明书

Anti-Human Complement C6 Recombinant Antibody (SAA0492).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Complement C6 Recombinant Antibody (SAA0492) (HY421013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Complement C6 Recombinant Antibody (SAA0492) (HY421013)

概述

图片

参考文献

产品说明书

相关产品推荐

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