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Anti-C6 Polyclonal Antibody (ARO-A14124)

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概述
货号ARO-A14124
品牌ProteoGenix
描述
Anti-C6 Polyclonal Antibody (ARO-A14124) is a rabbit polyclonal antibody detecting Complement component C6, C6 in ELISA, IHC, WB. Suitable for Human, Pan troglodytes, Pongo pygmaeus.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Pan troglodytes, Pongo pygmaeus
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human C6 (Gln682-Ala934).
靶标Complement component C6, C6
纯化方式Purified by antigen affinity column.
Accession号P13671
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Complement component C6 (Complement C6) is a ~104 kDa protein. Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending.

1. Aleshin, AE. et al. (2012) The Journal of biological chemistry 287, 10210-10222. PMID: 22267737
2. Hadders, MA. et al. (2012) Cell reports 1, 200-7. PMID: 22832194
3. Serna, M. et al. (2016) Nature communications 7, 10587. PMID: 26841837
4. Sharp, TH. et al. (2016) Cell reports 15, 1-8. PMID: 27052168
5. Menny, A. et al. (2018) Nature communications 9, 5316. PMID: 30552328
6. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456
7. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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