Anti-Human Angiopoietin-2 Recombinant Nanobody (SAA1255) (HT073013)

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50ug
100ug
1mg

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概述
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参考文献
产品说明书

概述

货号

HT073013

品牌

abinScience

描述

Anti-Human ANGPT2/Ang2 Nanobody (SAA1255) [SAA1255] (HT073013) is a alpaca monoclonal antibody detecting ANGPT2 in ELISA. Suitable for Human.

种属反应性

Human

应用

ELISA

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA1255

靶标

ANG-2, ANGPT2, Angiopoietin-2

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

O15123

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.

1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220

2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766

3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473

4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896

5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human ANGPT2/Ang2 Nanobody (SAA1255)
Bioactivity

Detects ANGPT2 (Catalog No: HT073041) in indirect ELISA.

参考文献

产品说明书

Anti-Human Angiopoietin-2 Recombinant Nanobody (SAA1255).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Angiopoietin-2 Recombinant Nanobody (SAA1255) (HT073013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human Angiopoietin-2 Recombinant Nanobody (SAA1255) (HT073013)

概述

图片

参考文献

产品说明书

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