Anti-Human BIRC5 Recombinant Nanobody (SAA1237) (HT337013)

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50ug
100ug
1mg

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概述
图片
参考文献
产品说明书

概述

货号

HT337013

品牌

abinScience

描述

Anti-Human BIRC5 Nanobody (SAA1237) [SAA1237] (HT337013) is a alpaca monoclonal antibody detecting BIRC5 in ELISA, SPR. Suitable for Human.

种属反应性

Human

应用

ELISA, SPR

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA1237

靶标

BIRC5, IAP4, Apoptosis inhibitor survivin, Apoptosis inhibitor 4, API4, Baculoviral IAP repeat-containing protein 5

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

O15392

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Baculoviral IAP repeat-containing protein 5 (BIRC5) is a ~16 kDa protein. Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.

1. Habtemichael, N. et al. (2010) Molecular and cellular neurosciences 45, 297-305. PMID: 20627126

2. Knauer, SK. et al. (2010) Cell death & disease 1, e51. PMID: 21364656

3. Liu, Y. et al. (2015) The Journal of biological chemistry 290, 11843-52. PMID: 25778398

4. Kamran, M. et al. (2017) Oncogenesis 6, e298. PMID: 28218735

5. Li, F. et al. (1998) Nature 396, 580-4. PMID: 9859993

6. Vong, QP. et al. (2005) Science (New York, N.Y.) 310, 1499-504. PMID: 16322459

7. Wang, H. et al. (2010) The Journal of biological chemistry 285, 36129-37. PMID: 20826784

8. Yamagishi, Y. et al. (2010) Science (New York, N.Y.) 330, 239-43. PMID: 20929775

9. Xia, F. et al. (2008) Molecular and cellular biology 28, 5299-311. PMID: 18591255

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human BIRC5 Nanobody (SAA1237)

参考文献

产品说明书

Anti-Human BIRC5 Recombinant Nanobody (SAA1237).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human BIRC5 Recombinant Nanobody (SAA1237) (HT337013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human BIRC5 Recombinant Nanobody (SAA1237) (HT337013)

概述

图片

参考文献

产品说明书

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