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Anti-BIRC5 Polyclonal Antibody (PTX19451)

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概述
货号PTX19451
品牌ProteoGenix
描述
Anti-BIRC5 Polyclonal Antibody (PTX19451) is a rabbit polyclonal antibody detecting BIRC5,IAP4,Apoptosis inhibitor survivin,Apoptosis inhibitor 4,API4,Baculoviral IAP repeat-containing protein 5 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human BIRC5 (Met1-Asp142).
靶标BIRC5,IAP4,Apoptosis inhibitor survivin,Apoptosis inhibitor 4,API4,Baculoviral IAP repeat-containing protein 5
纯化方式Purified by antigen affinity column.
Accession号O15392
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Baculoviral IAP repeat-containing protein 5 (BIRC5) is a ~16 kDa protein. Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.

1. Habtemichael, N. et al. (2010) Molecular and cellular neurosciences 45, 297-305. PMID: 20627126
2. Knauer, SK. et al. (2010) Cell death & disease 1, e51. PMID: 21364656
3. Liu, Y. et al. (2015) The Journal of biological chemistry 290, 11843-52. PMID: 25778398
4. Kamran, M. et al. (2017) Oncogenesis 6, e298. PMID: 28218735
5. Li, F. et al. (1998) Nature 396, 580-4. PMID: 9859993
6. Vong, QP. et al. (2005) Science (New York, N.Y.) 310, 1499-504. PMID: 16322459
7. Wang, H. et al. (2010) The Journal of biological chemistry 285, 36129-37. PMID: 20826784
8. Yamagishi, Y. et al. (2010) Science (New York, N.Y.) 330, 239-43. PMID: 20929775
9. Xia, F. et al. (2008) Molecular and cellular biology 28, 5299-311. PMID: 18591255
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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