Anti-Human LRP-6 Recombinant Nanobody (SAA0903) (HF964023)

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50ug
100ug
1mg

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概述
图片
参考文献
产品说明书

概述

货号

HF964023

品牌

abinScience

描述

Anti-Human LRP6 Nanobody (SAA0903) [SAA0903] (HF964023) is a alpaca monoclonal antibody detecting LRP6 in ELISA. Suitable for Human.

种属反应性

Human

应用

ELISA

宿主

Alpaca

克隆类型

Monoclonal

同种型

VHH-8His-Cys-tag

克隆号

SAA0903

靶标

LRP6, LRP-6, Low-density lipoprotein receptor-related protein 6

内毒素水平

< 10 EU/mg as determined by LAL method.

纯度

>95% as determined by SDS-PAGE.

纯化方式

Purified by Nickel column.

Accession号

O75581

状态

Liquid

保存溶液

0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Low-density lipoprotein receptor-related protein 6 (LRP6) is a ~180 kDa protein. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.

1. Mao, B. et al. (2001) Nature 411, 321-5. PMID: 11357136

2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771

3. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503

4. Zeng, X. et al. (2005) Nature 438, 873-7. PMID: 16341017

5. Swiatek, W. et al. (2006) The Journal of biological chemistry 281, 12233-41. PMID: 16513652

6. Mi, K. et al. (2007) Journal of neurochemistry 101, 517-29. PMID: 17326769

7. Wei, Q. et al. (2007) The Journal of biological chemistry 282, 15903-11. PMID: 17400545

8. Piao, S. et al. (2008) PloS one 3, e4046. PMID: 19107203

9. Wu, G. et al. (2009) PloS one 4, e4926. PMID: 19293931

10. Chen, M. et al. (2009) The Journal of biological chemistry 284, 35040-8. PMID: 19801552

Note

For research use only.

图片

SDS-PAGE

SDS-PAGE for Anti-Human LRP6 Nanobody (SAA0903)

参考文献

产品说明书

Anti-Human LRP-6 Recombinant Nanobody (SAA0903).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LRP-6 Recombinant Nanobody (SAA0903) (HF964023)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LRP-6 Recombinant Nanobody (SAA0903) (HF964023)

概述

图片

参考文献

产品说明书

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