Anti-Human LRP-6 Reference Antibody (GSK3178022, RUO) (HF964016)

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货号	HF964016
品牌	abinScience
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
同种型	IgG1-kappa
克隆号	GSK3178022
表达系统	Mammalian cells
靶标	LRP6, LRP-6, Low-density lipoprotein receptor-related protein 6
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	O75581
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	GSK3178022
背景	Low-density lipoprotein receptor-related protein 6 (LRP6) is a ~180 kDa protein. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in various processes including retinal angiogenesis and bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. 1. Mao, B. et al. (2001) Nature 411, 321-5. PMID: 11357136 2. Semënov, MV. et al. (2001) Current biology : CB 11, 951-61. PMID: 11448771 3. Li, X. et al. (2005) The Journal of biological chemistry 280, 19883-7. PMID: 15778503 4. Zeng, X. et al. (2005) Nature 438, 873-7. PMID: 16341017 5. Swiatek, W. et al. (2006) The Journal of biological chemistry 281, 12233-41. PMID: 16513652 6. Mi, K. et al. (2007) Journal of neurochemistry 101, 517-29. PMID: 17326769 7. Wei, Q. et al. (2007) The Journal of biological chemistry 282, 15903-11. PMID: 17400545 8. Piao, S. et al. (2008) PloS one 3, e4046. PMID: 19107203 9. Wu, G. et al. (2009) PloS one 4, e4926. PMID: 19293931 10. Chen, M. et al. (2009) The Journal of biological chemistry 284, 35040-8. PMID: 19801552
文献	1. Jackson H, et al. Novel Bispecific Domain Antibody to LRP6 Inhibits Wnt and R-spondin Ligand-Induced Wnt Signaling and Tumor Growth. Mol Cancer Res. 2016 Sep;14(9):859-68. [HF964016]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human LRP6 (GSK3178022)

产品说明书

Anti-Human LRP-6 Reference Antibody (GSK3178022, RUO).pdf

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C₁ (起始浓度)

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Anti-Human LRP-6 Reference Antibody (GSK3178022, RUO) (HF964016)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human LRP-6 Reference Antibody (GSK3178022, RUO) (HF964016)

概述

图片

参考文献

产品说明书

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