| 靶标 | TMS1, CARD5, Caspase recruitment domain-containing protein 5, Apoptosis-associated speck-like protein containing a CARD, PYD and CARD domain-containing protein, ASC, PYCARD, hASC, Target of methylation-induced silencing 1 |
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| 背景 | Apoptosis-associated speck-like protein containing a CARD (ASC/TMS1) is a ~21 kDa protein. Functions as a key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes (NLRP1, NLRP2, NLRP3, NLRP6, AIM2 and probably IFI16) which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines. Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death. 1. McConnell, BB. et al. (2000) Cancer research 60, 6243-7. PMID: 111037772. Masumoto, J. et al. (2003) Biochemical and biophysical research communications 303, 69-73. PMID: 126461684. Faustin, B. et al. (2007) Molecular cell 25, 713-24. PMID: 173499575. Fernandes-Alnemri, T. et al. (2007) Cell death and differentiation 14, 1590-604. PMID: 175990957. Fernandes-Alnemri, T. et al. (2009) Nature 458, 509-13. PMID: 191586768. Bryan, NB. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 3173-82. PMID: 192342159. Hasegawa, M. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 7655-62. PMID: 1949428910. Taxman, DJ. et al. (2011) The Journal of biological chemistry 286, 19605-16. PMID: 21487011 |
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