Anti-Human LAMTOR3/MAP2K1IP1 Recombinant Antibody (SAA1946) (HV209013)

Anti-Human LAMTOR3/MAP2K1IP1 Antibody (SAA1946) (abinScience Cat# HV209013, RRID:AB_3727710)
_x005F_x000D_ Copy Citation

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Ragulator complex protein LAMTOR3 is a ~13 kDa protein. As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.