| 靶标 | HIST1H4D, HIST2H4A, H4FE, H4FO, H4/D, H4/A, HIST1H4E, HIST1H4F, H4FG, HIST1H4L, H4FD, H4/H, HIST1H4B, HIST1H4I, H4FN, HIST1H4C, H4FI, H4FC, H4/C, H4/E, Histone H4, H4/G, H4/O, H4FB, H4FK, H4/M, H4/B, H4C1, HIST2H4, H4F2, HIST2H4B, HIST1H4A, HIST1H4J, H4/N, H4FH, H4/I, H4/J, H4/K, H4FJ, HIST1H4H, HIST1H4K, HIST4H4, H4FM, H4FA |
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| 背景 | Histone H4 (Di-acetylated histone H4 Lys5/Lys8 (H4K5acK8ac)) is a ~11 kDa protein. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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