

| 货号 | HY038045 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Anti-sCD14 Monoclonal Antibody (1A454) [1A454] (HY038045) is a mouse monoclonal antibody detecting CD14 in ELISA. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA |
| 宿主 | Mouse |
| 同种型 | IgG1 |
| 克隆号 | 1A454 |
| 克隆类型 | Monoclonal |
| 免疫原 | Mammalian cells - derived recombinant Human CD14 (Met1-Ala83). |
| 靶标 | Myeloid cell-specific leucine-rich glycoprotein, CD14, Monocyte differentiation antigen CD14 |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P08571 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 别名 | Monocyte differentiation antigen CD14, My23 antigen, Myeloid cell-specific leucine-rich glycoprotein, CD14, Monocyte differentiation antigen CD14 urinary form, Monocyte differentiation antigen CD14 membrane-bound form, CD14 |
| 背景 | Monocyte differentiation antigen CD14 is a ~40 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). 1. Wright, SD. et al. (1990) Science (New York, N.Y.) 249, 1431-3. PMID: 1698311 2. Kelley, SL. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1304-11. PMID: 23264655 3. Tsukamoto, H. et al. (2010) International immunology 22, 271-80. PMID: 20133493 4. Murakami, K. et al. (2012) FEBS letters 586, 319-24. PMID: 22265692 5. Haziot, A. et al. (1996) Immunity 4, 407-14. PMID: 8612135 6. Triantafilou, M. et al. (2006) The Journal of biological chemistry 281, 31002-11. PMID: 16880211 7. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187 |
| Note | For research use only. |

SDS-PAGE for Anti-sCD14 Monoclonal Antibody (1A454)



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