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Anti-GREM1 Polyclonal Antibody (PTX19463)

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概述
货号PTX19463
品牌ProteoGenix
描述
Anti-GREM1 Polyclonal Antibody (PTX19463) is a rabbit polyclonal antibody detecting Cysteine knot superfamily 1,BMP antagonist 1,CKTSF1B1,Down-regulated in Mos-transformed cells protein,Increased in high glucose protein 2,IHG-2,DRM,GREM1,Gremlin-1,Cell proliferation-inducing gene 2 protein,DAN domain family member 2,DAND2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GREM1 (Lys26-Asp184).
靶标Cysteine knot superfamily 1,BMP antagonist 1,CKTSF1B1,Down-regulated in Mos-transformed cells protein,Increased in high glucose protein 2,IHG-2,DRM,GREM1,Gremlin-1,Cell proliferation-inducing gene 2 protein,DAN domain family member 2,DAND2
纯化方式Purified by antigen affinity column.
Accession号O60565
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Gremlin-1 (GREM1/DAND2) is a ~20 kDa protein. Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.

1. Kišonaitė, M. et al. (2016) The Biochemical journal 473, 1593-604. PMID: 27036124
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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