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Anti-ABCA1 Polyclonal Antibody (PTX19475)

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概述
货号PTX19475
品牌ProteoGenix
描述
Anti-ABCA1 Polyclonal Antibody (PTX19475) is a rabbit polyclonal antibody detecting ATP-binding cassette transporter 1,ATP-binding cassette sub-family A member 1,Phospholipid-transporting ATPase ABCA1,ABC-1,ABCA1,ATP-binding cassette 1,Cholesterol efflux regulatory protein,ABC1,CERP in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human ABCA1 (Ser45-Glu271).
靶标ATP-binding cassette transporter 1,ATP-binding cassette sub-family A member 1,Phospholipid-transporting ATPase ABCA1,ABC-1,ABCA1,ATP-binding cassette 1,Cholesterol efflux regulatory protein,ABC1,CERP
纯化方式Purified by antigen affinity column.
Accession号O95477
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Phospholipid-transporting ATPase ABCA1 is a ~254 kDa protein. Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain.

1. Quazi, F. et al. (2013) The Journal of biological chemistry 288, 34414-26. PMID: 24097981
2. Segrest, JP. et al. (2022) Nature communications 13, 4812. PMID: 35974019
3. Krimbou, L. et al. (2004) Journal of lipid research 45, 839-48. PMID: 14754908
4. Marcil, M. et al. (1999) Lancet (London, England) 354, 1341-6. PMID: 10533863
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-ABCA1 Polyclonal Antibody

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