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Anti-RARA Polyclonal Antibody (PTX19556)

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概述
货号PTX19556
品牌ProteoGenix
描述
Anti-RARA Polyclonal Antibody (PTX19556) is a rabbit polyclonal antibody detecting RARA,Retinoic acid receptor alpha,Nuclear receptor subfamily 1 group B member 1,RAR-alpha,NR1B1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human RARA (Ser68-Glu173).
靶标RARA,Retinoic acid receptor alpha,Nuclear receptor subfamily 1 group B member 1,RAR-alpha,NR1B1
纯化方式Purified by antigen affinity column.
Accession号P10276
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Retinoic acid receptor alpha (RARA) is a ~50 kDa protein. Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation.

1. Srinivas, H. et al. (2006) The Biochemical journal 395, 653-62. PMID: 16417524
2. Zhu, L. et al. (2009) Endocrinology 150, 5586-95. PMID: 19850744
3. Santos, NC. et al. (2010) Endocrinology 151, 2361-72. PMID: 20215566
4. Sato, Y. et al. (2010) PloS one 5, e15119. PMID: 21152046
5. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846
6. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758
7. Qin, Z. et al. (2009) Molecular and cellular biology 29, 3633-43. PMID: 19398580
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-RARA Polyclonal Antibody

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