Anti-RARA Polyclonal Antibody (HY483014)

价格:

规格：

50ug
100ug

数量：

联系我们

一键复制产品信息

概述
图片
参考文献
产品说明书

概述

货号

HY483014

品牌

abinScience

描述

Anti-RARA Polyclonal Antibody (HY483014) is a rabbit polyclonal antibody detecting RARA in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Coturnix japonica, and Danio rerio.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human RARA (Ser68-Glu173).

靶标

RARA, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1, RAR-alpha, NR1B1

纯化方式

Purified by antigen affinity column.

Accession号

P10276

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Retinoic acid receptor alpha (RARA) is a ~50 kDa protein. Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation.

1. Srinivas, H. et al. (2006) The Biochemical journal 395, 653-62. PMID: 16417524

2. Zhu, L. et al. (2009) Endocrinology 150, 5586-95. PMID: 19850744

3. Santos, NC. et al. (2010) Endocrinology 151, 2361-72. PMID: 20215566

4. Sato, Y. et al. (2010) PloS one 5, e15119. PMID: 21152046

5. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846

6. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758

7. Qin, Z. et al. (2009) Molecular and cellular biology 29, 3633-43. PMID: 19398580

Note

For research use only.

图片

参考文献

产品说明书

Anti-RARA Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-RARA Polyclonal Antibody (HY483014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-RARA Polyclonal Antibody (HY483014)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价