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Anti-BMP7 Polyclonal Antibody (PTX18485)

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概述
货号PTX18485
品牌ProteoGenix
描述
Anti-BMP7 Polyclonal Antibody (PTX18485) is a rabbit polyclonal antibody detecting Bone morphogenetic protein 7,Eptotermin alfa,OP-1,OP1,BMP-7,Osteogenic protein 1,BMP7 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human BMP7 (Asp30-His431).
靶标Bone morphogenetic protein 7,Eptotermin alfa,OP-1,OP1,BMP-7,Osteogenic protein 1,BMP7
纯化方式Purified by antigen affinity column.
Accession号P18075
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Bone morphogenetic protein 7 (BMP7) is a ~49 kDa protein. Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor.

1. Perron, JC. et al. (2019) Biology open 8. PMID: 31208997
2. Greenwald, J. et al. (2003) Molecular cell 11, 605-17. PMID: 12667445
3. Macías-Silva, M. et al. (1998) The Journal of biological chemistry 273, 25628-36. PMID: 9748228
4. Groppe, J. et al. (2002) Nature 420, 636-42. PMID: 12478285
5. Brunmeir, R. et al. (2016) PLoS genetics 12, e1006474. PMID: 27923061
6. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-BMP7 Polyclonal Antibody

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