Anti-BMP7 Polyclonal Antibody (HB664014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HB664014

品牌

abinScience

描述

Anti-BMP7 Polyclonal Antibody (HB664014) is a rabbit polyclonal antibody detecting BMP7 in ELISA, IHC, WB. Suitable for Human, Mouse, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human BMP7 (Asp30-His431).

靶标

Bone morphogenetic protein 7, Eptotermin alfa, OP-1, OP1, BMP-7, Osteogenic protein 1, BMP7

纯化方式

Purified by antigen affinity column.

Accession号

P18075

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Bone morphogenetic protein 7 (BMP7) is a ~49 kDa protein. Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor.

1. Perron, JC. et al. (2019) Biology open 8. PMID: 31208997

2. Greenwald, J. et al. (2003) Molecular cell 11, 605-17. PMID: 12667445

3. Macías-Silva, M. et al. (1998) The Journal of biological chemistry 273, 25628-36. PMID: 9748228

4. Groppe, J. et al. (2002) Nature 420, 636-42. PMID: 12478285

5. Brunmeir, R. et al. (2016) PLoS genetics 12, e1006474. PMID: 27923061

6. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509

Note

For research use only.

图片

参考文献

产品说明书

Anti-BMP7 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-BMP7 Polyclonal Antibody (HB664014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-BMP7 Polyclonal Antibody (HB664014)

概述

图片

参考文献

产品说明书

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