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Anti-CYP3A7 Polyclonal Antibody (PTX19630)

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概述
货号PTX19630
品牌ProteoGenix
描述
Anti-CYP3A7 Polyclonal Antibody (PTX19630) is a rabbit polyclonal antibody detecting CYP3A7,CYPIIIA7,P450HLp2,Cytochrome P450 3A7,Cytochrome P450-HFLA in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CYP3A7 (Pro344-Asp497).
靶标CYP3A7,CYPIIIA7,P450HLp2,Cytochrome P450 3A7,Cytochrome P450-HFLA
纯化方式Purified by antigen affinity column.
Accession号P24462
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cytochrome P450 3A7 (CYP3A7) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position.

1. Marill, J. et al. (2000) Molecular pharmacology 58, 1341-8. PMID: 11093772
2. Lee, AJ. et al. (2003) Endocrinology 144, 3382-98. PMID: 12865317
3. Lee, AJ. et al. (2003) Cancer research 63, 6532-6. PMID: 14559847
4. Torimoto, N. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 484-92. PMID: 17178770
5. Ohmori, S. et al. (1998) Biochimica et biophysica acta 1380, 297-304. PMID: 9555064
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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