Anti-CYP3A7 Polyclonal Antibody (HB872014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HB872014

品牌

abinScience

描述

Anti-CYP3A7 Polyclonal Antibody (HB872014) is a rabbit polyclonal antibody detecting CYP3A7 in ELISA, IHC, WB. Suitable for Human, Callithrix jacchus, and Macaca fascicularis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human CYP3A7 (Pro344-Asp497).

靶标

CYP3A7, CYPIIIA7, P450HLp2, Cytochrome P450 3A7, Cytochrome P450-HFLA

纯化方式

Purified by antigen affinity column.

Accession号

P24462

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Cytochrome P450 3A7 (CYP3A7) is a ~57 kDa protein. A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position.

1. Marill, J. et al. (2000) Molecular pharmacology 58, 1341-8. PMID: 11093772

2. Lee, AJ. et al. (2003) Endocrinology 144, 3382-98. PMID: 12865317

3. Lee, AJ. et al. (2003) Cancer research 63, 6532-6. PMID: 14559847

4. Torimoto, N. et al. (2007) Drug metabolism and disposition: the biological fate of chemicals 35, 484-92. PMID: 17178770

5. Ohmori, S. et al. (1998) Biochimica et biophysica acta 1380, 297-304. PMID: 9555064

Note

For research use only.

图片

参考文献

产品说明书

Anti-CYP3A7 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CYP3A7 Polyclonal Antibody (HB872014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-CYP3A7 Polyclonal Antibody (HB872014)

概述

图片

参考文献

产品说明书

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