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Anti-TTK Polyclonal Antibody (PTX19670)

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概述
货号PTX19670
品牌ProteoGenix
描述
Anti-TTK Polyclonal Antibody (PTX19670) is a rabbit polyclonal antibody detecting Dual specificity protein kinase TTK,MPS1L1,Phosphotyrosine picked threonine-protein kinase,TTK,PYT,MPS1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human TTK (Gly532-Ala787).
靶标Dual specificity protein kinase TTK,MPS1L1,Phosphotyrosine picked threonine-protein kinase,TTK,PYT,MPS1
纯化方式Purified by antigen affinity column.
Accession号P33981
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Dual specificity protein kinase TTK is a ~97 kDa protein. Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates.

1. Jelluma, N. et al. (2008) Cell 132, 233-46. PMID: 18243099
2. Maciejowski, J. et al. (2017) Developmental cell 41, 143-156.e6. PMID: 28441529
3. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720
4. Yang, H. et al. (2019) Molecular biology of the cell 30, 1060-1068. PMID: 30785839
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-TTK Polyclonal Antibody

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