Anti-TTK Polyclonal Antibody (HW490014)

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概述
图片
参考文献
产品说明书

概述

货号

HW490014

品牌

abinScience

描述

Anti-TTK Polyclonal Antibody (HW490014) is a rabbit polyclonal antibody detecting TTK in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human TTK (Gly532-Ala787).

靶标

Dual specificity protein kinase TTK, MPS1L1, Phosphotyrosine picked threonine-protein kinase, TTK, PYT, MPS1

纯化方式

Purified by antigen affinity column.

Accession号

P33981

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Dual specificity protein kinase TTK is a ~97 kDa protein. Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates.

1. Jelluma, N. et al. (2008) Cell 132, 233-46. PMID: 18243099

2. Maciejowski, J. et al. (2017) Developmental cell 41, 143-156.e6. PMID: 28441529

3. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720

4. Yang, H. et al. (2019) Molecular biology of the cell 30, 1060-1068. PMID: 30785839

Note

For research use only.

图片

参考文献

产品说明书

Anti-TTK Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TTK Polyclonal Antibody (HW490014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-TTK Polyclonal Antibody (HW490014)

概述

图片

参考文献

产品说明书

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