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Anti-BMI1 Polyclonal Antibody (PTX18482)

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概述
货号PTX18482
品牌ProteoGenix
描述
Anti-BMI1 Polyclonal Antibody (PTX18482) is a rabbit polyclonal antibody detecting RING finger protein 51,BMI1,RNF51,Polycomb complex protein BMI-1,Polycomb group RING finger protein 4,PCGF4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human BMI1 (Glu152-Ile289).
靶标RING finger protein 51,BMI1,RNF51,Polycomb complex protein BMI-1,Polycomb group RING finger protein 4,PCGF4
纯化方式Purified by antigen affinity column.
Accession号P35226
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Polycomb complex protein BMI-1 (BMI1) is a ~36 kDa protein. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2.

1. Wang, H. et al. (2004) Nature 431, 873-8. PMID: 15386022
2. Cao, R. et al. (2005) Molecular cell 20, 845-54. PMID: 16359901
3. Li, Z. et al. (2006) The Journal of biological chemistry 281, 20643-9. PMID: 16714294
4. Bentley, ML. et al. (2011) The EMBO journal 30, 3285-97. PMID: 21772249
5. McGinty, RK. et al. (2014) Nature 514, 591-6. PMID: 25355358
6. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332
7. Gray, F. et al. (2016) Nature communications 7, 13343. PMID: 27827373
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-BMI1 Polyclonal Antibody

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