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Anti-GDF5 Polyclonal Antibody (PTX18573)

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概述
货号PTX18573
品牌ProteoGenix
描述
Anti-GDF5 Polyclonal Antibody (PTX18573) is a rabbit polyclonal antibody detecting Growth/differentiation factor 5,BMP14,BMP-14,Radotermin,GDF-5,Bone morphogenetic protein 14,GDF5,CDMP-1,Lipopolysaccharide-associated protein 4,LAP-4,CDMP1,Cartilage-derived morphogenetic protein 1,LPS-associated protein 4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human GDF5 (Ala382-Arg501).
靶标Growth/differentiation factor 5,BMP14,BMP-14,Radotermin,GDF-5,Bone morphogenetic protein 14,GDF5,CDMP-1,Lipopolysaccharide-associated protein 4,LAP-4,CDMP1,Cartilage-derived morphogenetic protein 1,LPS-associated protein 4
纯化方式Purified by antigen affinity column.
Accession号P43026
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Growth/differentiation factor 5 (GDF5) is a ~55 kDa protein. Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation.

1. Bai, X. et al. (2004) Biochemical and biophysical research communications 325, 453-60. PMID: 15530414
2. Schwaerzer, GK. et al. (2012) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27, 429-42. PMID: 21976273
3. Degenkolbe, E. et al. (2013) PLoS genetics 9, e1003846. PMID: 24098149
4. Stange, K. et al. (2014) Journal of molecular biology 426, 3221-3231. PMID: 25092592
5. Triantafilou, K. et al. (2001) Nature immunology 2, 338-45. PMID: 11276205
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-GDF5 Polyclonal Antibody

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