Anti-GDF5 Polyclonal Antibody (HW374014)

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概述
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参考文献
产品说明书

概述

货号

HW374014

品牌

abinScience

描述

Anti-GDF5 Polyclonal Antibody (HW374014) is a rabbit polyclonal antibody detecting GDF5 in ELISA, IHC, WB. Suitable for Mouse and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant Human GDF5 (Ala382-Arg501).

靶标

Growth/differentiation factor 5, BMP14, BMP-14, Radotermin, GDF-5, Bone morphogenetic protein 14, GDF5, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, CDMP1, Cartilage-derived morphogenetic protein 1, LPS-associated protein 4

纯化方式

Purified by antigen affinity column.

Accession号

P43026

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Growth/differentiation factor 5 (GDF5) is a ~55 kDa protein. Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation.

1. Bai, X. et al. (2004) Biochemical and biophysical research communications 325, 453-60. PMID: 15530414

2. Schwaerzer, GK. et al. (2012) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27, 429-42. PMID: 21976273

3. Degenkolbe, E. et al. (2013) PLoS genetics 9, e1003846. PMID: 24098149

4. Stange, K. et al. (2014) Journal of molecular biology 426, 3221-3231. PMID: 25092592

5. Triantafilou, K. et al. (2001) Nature immunology 2, 338-45. PMID: 11276205

Note

For research use only.

图片

参考文献

产品说明书

Anti-GDF5 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GDF5 Polyclonal Antibody (HW374014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GDF5 Polyclonal Antibody (HW374014)

概述

图片

参考文献

产品说明书

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