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Anti-CASP4 Polyclonal Antibody (PTX19713)

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概述
货号PTX19713
品牌ProteoGenix
描述
Anti-CASP4 Polyclonal Antibody (PTX19713) is a rabbit polyclonal antibody detecting Mih1,ICH2,CASP-4,ICE and Ced-3 homolog 2,CASP4,Protease TX,Caspase-4,ICE(rel)-II,ICH-2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human CASP4 (Asn78-Glu265).
靶标Mih1,ICH2,CASP-4,ICE and Ced-3 homolog 2,CASP4,Protease TX,Caspase-4,ICE(rel)-II,ICH-2
纯化方式Purified by antigen affinity column.
Accession号P49662
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Caspase-4 (CASP4) is a ~43 kDa protein. Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis. Also indirectly activates the NLRP3 and NLRP6 inflammasomes. Acts as a thiol protease that cleaves a tetrapeptide after an Asp residue at position P1: catalyzes cleavage of CGAS, GSDMD and IL18. Effector of the non-canonical inflammasome independently of NLRP3 inflammasome and CASP1: the non-canonical inflammasome promotes pyroptosis through GSDMD cleavage without involving secretion of cytokine IL1B. In the non-canonical inflammasome, CASP4 is activated by direct binding to the lipid A moiety of LPS without the need of an upstream sensor.

1. Shi, J. et al. (2014) Nature 514, 187-92. PMID: 25119034
2. Shi, J. et al. (2015) Nature 526, 660-5. PMID: 26375003
3. Wang, K. et al. (2020) Cell 180, 941-955.e20. PMID: 32109412
4. Li, Z. et al. (2021) Nature 599, 290-295. PMID: 34671164
5. Zhu, F. et al. (2023) Immunity 56, 753-767.e8. PMID: 37001519
6. Devant, P. et al. (2023) Nature 624, 451-459. PMID: 37993712
7. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714
8. Blasche, S. et al. (2013) PloS one 8, e58937. PMID: 23516580
10. Gaggero, A. et al. (2004) Oncogene 23, 7552-60. PMID: 15326478
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-CASP4 Polyclonal Antibody

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