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Anti-F2RL1 Polyclonal Antibody (PTX19730)

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概述
货号PTX19730
品牌ProteoGenix
描述
Anti-F2RL1 Polyclonal Antibody (PTX19730) is a rabbit polyclonal antibody detecting GPR11,Thrombin receptor-like 1,G-protein coupled receptor 11,F2RL1,PAR-2,Coagulation factor II receptor-like 1,Proteinase-activated receptor 2,PAR2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human F2RL1 (Leu15-Val87).
靶标GPR11,Thrombin receptor-like 1,G-protein coupled receptor 11,F2RL1,PAR-2,Coagulation factor II receptor-like 1,Proteinase-activated receptor 2,PAR2
纯化方式Purified by antigen affinity column.
Accession号P55085
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Proteinase-activated receptor 2 (F2RL1/PAR-2) is a ~44 kDa protein. Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation.

1. Cheng, RKY. et al. (2017) Nature 545, 112-115. PMID: 28445455
2. Kuckleburg, CJ. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 275-84. PMID: 23202369
3. Cocks, TM. et al. (1999) Nature 398, 156-60. PMID: 10086357
4. Botham, A. et al. (2011) The Biochemical journal 438, 359-67. PMID: 21627585
5. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-F2RL1 Polyclonal Antibody

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