Anti-Human F2RL1/PAR-2 Reference Antibody (PAR650097, RUO) (HX041016)

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概述

货号	HX041016
品牌	abinScience
描述	Anti-Human F2RL1/PAR-2 Antibody (PAR650097) (HX041016) is a research-grade recombinant antibody targeting GPR11. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	PAR650097
表达系统	Mammalian cells
靶标	GPR11, Thrombin receptor-like 1, G-protein coupled receptor 11, F2RL1, PAR-2, Coagulation factor II receptor-like 1, Proteinase-activated receptor 2, PAR2
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P55085
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	PAR650097, PAR650097, PAR-650097
背景	Proteinase-activated receptor 2 (F2RL1/PAR-2) is a ~44 kDa protein. Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. 1. Cheng, RKY. et al. (2017) Nature 545, 112-115. PMID: 28445455 2. Kuckleburg, CJ. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 275-84. PMID: 23202369 3. Cocks, TM. et al. (1999) Nature 398, 156-60. PMID: 10086357 4. Botham, A. et al. (2011) The Biochemical journal 438, 359-67. PMID: 21627585 5. Manithody, C. et al. (2012) Biochemistry 51, 2551-7. PMID: 22409427
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human F2RL1/PAR-2 Antibody (PAR650097)

参考文献

产品说明书

Anti-Human F2RL1/PAR-2 Reference Antibody (PAR650097, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human F2RL1/PAR-2 Reference Antibody (PAR650097, RUO) (HX041016)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human F2RL1/PAR-2 Reference Antibody (PAR650097, RUO) (HX041016)

概述

图片

参考文献

产品说明书

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