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Anti-BACE1 Polyclonal Antibody (PTX18481)

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概述
货号PTX18481
品牌ProteoGenix
描述
Anti-BACE1 Polyclonal Antibody (PTX18481) is a rabbit polyclonal antibody detecting BACE1,Memapsin-2,KIAA1149,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,BACE,Beta-site APP cleaving enzyme 1,Beta-secretase 1,Aspartyl protease 2,ASP2,Membrane-associated aspartic protease 2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human BACE1 (Glu46-Thr457).
靶标BACE1,Memapsin-2,KIAA1149,Asp 2,Beta-site amyloid precursor protein cleaving enzyme 1,BACE,Beta-site APP cleaving enzyme 1,Beta-secretase 1,Aspartyl protease 2,ASP2,Membrane-associated aspartic protease 2
纯化方式Purified by antigen affinity column.
Accession号P56817
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Beta-secretase 1 (BACE1) is a ~55 kDa protein. Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves CHL1.

1. Hussain, I. et al. (1999) Molecular and cellular neurosciences 14, 419-27. PMID: 10656250
2. Lin, X. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 1456-60. PMID: 10677483
3. Okada, H. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 2783-94. PMID: 20354142
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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