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Anti-SLC39A6 Polyclonal Antibody (PTX19773)

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概述
货号PTX19773
品牌ProteoGenix
描述
Anti-SLC39A6 Polyclonal Antibody (PTX19773) is a rabbit polyclonal antibody detecting SLC39A6,LIV1,Zrt- and Irt-like protein 6,Zinc transporter ZIP6,ZIP-6,Estrogen-regulated protein LIV-1,Solute carrier family 39 member 6,ZIP6 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SLC39A6 (Lys445-Gln656).
靶标SLC39A6,LIV1,Zrt- and Irt-like protein 6,Zinc transporter ZIP6,ZIP-6,Estrogen-regulated protein LIV-1,Solute carrier family 39 member 6,ZIP6
纯化方式Purified by antigen affinity column.
Accession号Q13433
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Zinc transporter ZIP6 (SLC39A6/LIV-1) is a ~85 kDa protein. Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis.

1. Taylor, KM. et al. (2003) The Biochemical journal 375, 51-9. PMID: 12839489
2. Chowanadisai, W. et al. (2008) Brain research 1199, 10-9. PMID: 18272141
3. Yu, M. et al. (2011) The Journal of experimental medicine 208, 775-85. PMID: 21422171
4. Hogstrand, C. et al. (2013) The Biochemical journal 455, 229-37. PMID: 23919497
5. Taylor, KM. et al. (2016) The Biochemical journal 473, 2531-44. PMID: 27274087
6. Kim, B. et al. (2021) Frontiers in immunology 12, 687367. PMID: 34394081
7. Nimmanon, T. et al. (2021) Cellular and molecular life sciences : CMLS 78, 1781-1798. PMID: 32797246
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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