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Anti-PDK1 Polyclonal Antibody (PTX19790)

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概述
货号PTX19790
品牌ProteoGenix
描述
Anti-PDK1 Polyclonal Antibody (PTX19790) is a rabbit polyclonal antibody detecting PDHK1,[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,mitochondrial,PDK1,Pyruvate dehydrogenase kinase isoform 1,PDH kinase 1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PDK1 (Tyr233-Met430).
靶标PDHK1,[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,mitochondrial,PDK1,Pyruvate dehydrogenase kinase isoform 1,PDH kinase 1
纯化方式Purified by antigen affinity column.
Accession号Q15118
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) is a ~49 kDa protein. Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia.

1. Gudi, R. et al. (1995) The Journal of biological chemistry 270, 28989-94. PMID: 7499431
2. McFate, T. et al. (2008) The Journal of biological chemistry 283, 22700-8. PMID: 18541534
3. Hitosugi, T. et al. (2011) Molecular cell 44, 864-77. PMID: 22195962
4. Li, X. et al. (2016) Molecular cell 61, 705-719. PMID: 26942675
5. Kato, M. et al. (2007) Structure (London, England : 1993) 15, 992-1004. PMID: 17683942
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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