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Anti-KCNK9 Polyclonal Antibody (PTX19855)

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概述
货号PTX19855
品牌ProteoGenix
描述
Anti-KCNK9 Polyclonal Antibody (PTX19855) is a rabbit polyclonal antibody detecting TASK3,KCNK9,Acid-sensitive potassium channel protein TASK-3,Potassium channel subfamily K member 9,Two pore K(+) channel KT3.2,TWIK-related acid-sensitive K(+) channel 3,Two pore potassium channel KT3.2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human KCNK9 (Asn240-Val374).
靶标TASK3,KCNK9,Acid-sensitive potassium channel protein TASK-3,Potassium channel subfamily K member 9,Two pore K(+) channel KT3.2,TWIK-related acid-sensitive K(+) channel 3,Two pore potassium channel KT3.2
纯化方式Purified by antigen affinity column.
Accession号Q9NPC2
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Potassium channel subfamily K member 9 (KCNK9) is a ~42 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties.

1. Chapman, CG. et al. (2000) Brain research. Molecular brain research 82, 74-83. PMID: 11042359
2. Vega-Saenz de Miera, E. et al. (2001) Journal of neurophysiology 86, 130-42. PMID: 11431495
3. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430
4. Lin, H. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2320345121. PMID: 38630723
5. Ma, L. et al. (2012) The Journal of biological chemistry 287, 37145-53. PMID: 22948150
6. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-KCNK9 Polyclonal Antibody

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