Affinity Purified — Minimal background and high purity for reliable results.
Multi-Application — Validated across multiple applications.
种属反应性
Human
应用
ELISA, IHC, WB
宿主
Rabbit
克隆类型
Polyclonal
同种型
IgG
免疫原
E. coli - derived recombinant Human CD85d/LILRB2 (Leu53-Val255).
靶标
CD85 antigen-like family member D,Monocyte/macrophage immunoglobulin-like receptor 10,MIR-10,ILT4,LIR-2,ILT-4,Immunoglobulin-like transcript 4,MIR10,CD85d,Leukocyte immunoglobulin-like receptor subfamily B member 2,Leukocyte immunoglobulin-like receptor 2,LIR2,LILRB2
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景
Leukocyte immunoglobulin-like receptor subfamily B member 2 (CD85d/LILRB2) is a ~65 kDa protein. Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens.
1. Lepin, EJ. et al. (2000) European journal of immunology 30, 3552-61. PMID: 11169396
2. Shiroishi, M. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8856-61. PMID: 12853576
3. Shiroishi, M. et al. (2006) The Journal of biological chemistry 281, 10439-47. PMID: 16455647
4. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 20448110
5. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042
6. Chang, CC. et al. (2002) Nature immunology 3, 237-43. PMID: 11875462
8. Fanger, NA. et al. (1998) European journal of immunology 28, 3423-34. PMID: 9842885
