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Anti-Human PANX1 Polyclonal Antibody (PTX20134)

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概述
货号PTX20134
品牌ProteoGenix
描述
Anti-Human PANX1 Polyclonal Antibody (PTX20134) is a rabbit polyclonal antibody detecting MRS1, Pannexin-1, PANX1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human PANX1 (Ser236-Gln274).
靶标MRS1, Pannexin-1, PANX1
纯化方式Purified by antigen affinity column.
Accession号Q96RD7
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Pannexin-1 (PANX1) is a ~48 kDa protein. Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis. Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate. Can release ATP upon activation through phosphorylation or cleavage at C-terminus. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.

1. Bao, L. et al. (2004) FEBS letters 572, 65-8. PMID: 15304325
2. Vanden Abeele, F. et al. (2006) The Journal of cell biology 174, 535-46. PMID: 16908669
3. Bunse, S. et al. (2010) The Journal of biological chemistry 285, 38444-52. PMID: 20829356
4. Chekeni, FB. et al. (2010) Nature 467, 863-7. PMID: 20944749
5. Sang, Q. et al. (2019) Science translational medicine 11. PMID: 30918116
6. Medina, CB. et al. (2020) Nature 580, 130-135. PMID: 32238926
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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