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Anti-Human RIOK3 Polyclonal Antibody (PTX20270)

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概述
货号PTX20270
品牌ProteoGenix
描述
Anti-Human RIOK3 Polyclonal Antibody (PTX20270) is a rabbit polyclonal antibody detecting Serine/threonine-protein kinase RIO3, SUDD, sudD homolog, RIO kinase 3, RIOK3 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human RIOK3 (Ser247-Glu519).
靶标Serine/threonine-protein kinase RIO3, SUDD, sudD homolog, RIO kinase 3, RIOK3
纯化方式Purified by antigen affinity column.
Accession号O14730
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Serine/threonine-protein kinase RIO3 (RIOK3) is a ~59 kDa protein. Serine/threonine-protein kinase involved in a ribosome quality control that takes place when ribosomes have stalled, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. Acts downstream of RNF10: specifically recognizes and binds RPS2/us5 and RPS3/us3 monoubiquitinated by RNF10, promoting degradation of the 40S ribosomal subunit in a kinase-dependent manner. The RNF10-RIOK3 ribosome quality control takes place in response to ribosome subunit imbalance or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). Also involved in regulation of type I interferon (IFN)-dependent immune response, possibly by acting as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling.

1. Coria, AR. et al. (2025) Molecular cell 85, 787-801.e8. PMID: 39947182
2. Huang, Z. et al. (2025) Molecular cell 85, 802-814.e12. PMID: 39947183
3. Ford, PW. et al. (2025) Cell reports 44, 115371. PMID: 40022732
4. Feng, J. et al. (2014) Journal of virology 88, 7987-97. PMID: 24807708
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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