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Anti-MDM2 Polyclonal Antibody (PTX20286)

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概述
货号PTX20286
品牌ProteoGenix
描述
Anti-MDM2 Polyclonal Antibody (PTX20286) is a rabbit polyclonal antibody detecting MDM2, Hdm2, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3 ubiquitin transferase Mdm2, Double minute 2 protein, Oncoprotein Mdm2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
同种型IgG
克隆类型Polyclonal
免疫原E. coli - derived recombinant Human MDM2 (Asn3-Pro491).
靶标MDM2, Hdm2, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3 ubiquitin transferase Mdm2, Double minute 2 protein, Oncoprotein Mdm2
纯化方式Purified by antigen affinity column.
Accession号Q00987
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

E3 ubiquitin-protein ligase Mdm2 is a ~55 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.

1. Liang, L. et al. (2018) Cell chemical biology 25, 761-774.e5. PMID: 29681526
2. Girnita, L. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8247-52. PMID: 12821780
3. Li, M. et al. (2004) Molecular cell 13, 879-86. PMID: 15053880
4. Bernardi, R. et al. (2004) Nature cell biology 6, 665-72. PMID: 15195100
5. Brady, M. et al. (2005) Molecular and cellular biology 25, 545-53. PMID: 15632057
6. Sdek, P. et al. (2005) Molecular cell 20, 699-708. PMID: 16337594
7. Stevenson, LF. et al. (2007) The EMBO journal 26, 976-86. PMID: 17290220
8. Chen, D. et al. (2009) EMBO reports 10, 166-72. PMID: 19098711
9. Busso, CS. et al. (2009) Oncogene 28, 1616-25. PMID: 19219073
10. Li, DQ. et al. (2009) The Journal of biological chemistry 284, 34545-52. PMID: 19837670
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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