Anti-Human MDM2 Reference Antibody (OM-301, RUO) (HX174036)

价格:

规格：

100ug
1mg
5mg
10mg
25mg
50mg
100mg

数量：

联系我们

一键复制产品信息

概述
图片
参考文献
产品说明书

概述

货号	HX174036
品牌	abinScience
描述	Anti-Human MDM2 (OM-301) (HX174036) is a research-grade recombinant antibody targeting MDM2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
种属反应性	Human
应用	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主	Human
同种型	IgG
克隆号	OM-301
表达系统	Mammalian cells
克隆类型	Monoclonal
靶标	MDM2, Hdm2, p53-binding protein Mdm2, E3 ubiquitin-protein ligase Mdm2, RING-type E3 ubiquitin transferase Mdm2, Double minute 2 protein, Oncoprotein Mdm2
内毒素水平	< 10 EU/mg
纯度	>95% purity as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	Q00987
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名	OM-301, OM301, OM301
背景	E3 ubiquitin-protein ligase Mdm2 is a ~55 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. 1. Liang, L. et al. (2018) Cell chemical biology 25, 761-774.e5. PMID: 29681526 2. Girnita, L. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 8247-52. PMID: 12821780 3. Li, M. et al. (2004) Molecular cell 13, 879-86. PMID: 15053880 4. Bernardi, R. et al. (2004) Nature cell biology 6, 665-72. PMID: 15195100 5. Brady, M. et al. (2005) Molecular and cellular biology 25, 545-53. PMID: 15632057 6. Sdek, P. et al. (2005) Molecular cell 20, 699-708. PMID: 16337594 7. Stevenson, LF. et al. (2007) The EMBO journal 26, 976-86. PMID: 17290220 8. Chen, D. et al. (2009) EMBO reports 10, 166-72. PMID: 19098711 9. Busso, CS. et al. (2009) Oncogene 28, 1616-25. PMID: 19219073 10. Li, DQ. et al. (2009) The Journal of biological chemistry 284, 34545-52. PMID: 19837670
Note	For research use only. Not suitable for clinical or therapeutic use.

图片

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human MDM2 (OM-301)

参考文献

产品说明书

Anti-Human MDM2 Reference Antibody (OM-301, RUO).pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MDM2 Reference Antibody (OM-301, RUO) (HX174036)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MDM2 Reference Antibody (OM-301, RUO) (HX174036)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价