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Anti-HMGB1 Polyclonal Antibody (PTX20297)

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概述
货号PTX20297
品牌ProteoGenix
描述
Anti-HMGB1 Polyclonal Antibody (PTX20297) is a rabbit polyclonal antibody detecting High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human HMGB1 (Met1-Glu215).
靶标High mobility group protein B1, HMGB1, HMG1, HMG-1, High mobility group protein 1
纯化方式Purified by antigen affinity column.
Accession号P09429
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

High mobility group protein B1 (HMGB1) is a ~24 kDa protein. Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as a sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy.

1. Wei, J. et al. (2021) Cell 184, 76-91.e13. PMID: 33147444
2. Avgousti, DC. et al. (2016) Nature 535, 173-7. PMID: 27362237
3. Wang, G. et al. (2021) Cell death discovery 7, 337. PMID: 34743181
4. Yang, H. et al. (2013) Journal of leukocyte biology 93, 865-73. PMID: 23446148
5. Li, G. et al. (2013) Frontiers in immunology 4, 68. PMID: 23519706
6. Li, G. et al. (2013) Seminars in cancer biology 23, 380-90. PMID: 23994764
7. Lee, SA. et al. (2014) Yonsei medical journal 55, 1165-76. PMID: 25048472
8. Min, HJ. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 1797-806. PMID: 23303669
9. Lee, LC. et al. (2014) PloS one 9, e115809. PMID: 25549101
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-HMGB1 Polyclonal Antibody

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