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Anti-VDR Polyclonal Antibody (PTX20407)

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概述
货号PTX20407
品牌ProteoGenix
描述
Anti-VDR Polyclonal Antibody (PTX20407) is a rabbit polyclonal antibody detecting VDR, Vitamin D3 receptor, 1,25-dihydroxyvitamin D3 receptor, NR1I1, Nuclear receptor subfamily 1 group I member 1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human VDR (Met272-Ser427).
靶标VDR, Vitamin D3 receptor, 1,25-dihydroxyvitamin D3 receptor, NR1I1, Nuclear receptor subfamily 1 group I member 1
纯化方式Purified by antigen affinity column.
Accession号P11473
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Vitamin D3 receptor (VDR) is a ~48 kDa protein. Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites.

1. Rochel, N. et al. (2000) Molecular cell 5, 173-9. PMID: 10678179
2. Eelen, G. et al. (2005) Molecular pharmacology 67, 1566-73. PMID: 15728261
3. Hourai, S. et al. (2006) Journal of medicinal chemistry 49, 5199-205. PMID: 16913708
4. Tamura, M. et al. (2017) Scientific reports 7, 5102. PMID: 28698609
5. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846
6. Makishima, M. et al. (2002) Science (New York, N.Y.) 296, 1313-6. PMID: 12016314
7. Hashimoto, N. et al. (2020) Kidney international 97, 1164-1180. PMID: 32354638
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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