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Anti-ADRA1A Polyclonal Antibody (PTX20447)

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概述
货号PTX20447
品牌ProteoGenix
描述
Anti-ADRA1A Polyclonal Antibody (PTX20447) is a rabbit polyclonal antibody detecting ADRA1C, ADRA1A, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, Alpha-1A adrenoceptor, Alpha-1A adrenergic receptor in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
  • Multi-Species — Cross-reactive for translational research.
种属反应性Human, Mouse, Rat
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human ADRA1A (Ser330-Val466).
靶标ADRA1C, ADRA1A, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, Alpha-1A adrenoceptor, Alpha-1A adrenergic receptor
纯化方式Purified by antigen affinity column.
Accession号P35348
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Alpha-1A adrenergic receptor (ADRA1A) is a ~51 kDa protein. Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1A binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) protein. Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.

1. Su, M. et al. (2023) Nature communications 14, 4819. PMID: 37563160
2. Wright, CD. et al. (2008) Circulation research 103, 992-1000. PMID: 18802028
3. Schwinn, DA. et al. (1995) The Journal of pharmacology and experimental therapeutics 272, 134-42. PMID: 7815325
4. Weinberg, DH. et al. (1994) Biochemical and biophysical research communications 201, 1296-304. PMID: 8024574
5. Forray, C. et al. (1994) Molecular pharmacology 45, 703-8. PMID: 8183249
6. Shibata, K. et al. (1996) British journal of pharmacology 118, 1403-8. PMID: 8832064
7. Wright, CD. et al. (2012) Cellular signalling 24, 794-802. PMID: 22120526
8. Ogata, T. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 3811-6. PMID: 24567387
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-ADRA1A Polyclonal Antibody

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