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Anti-Human SETD7 Polyclonal Antibody (PTX20542)

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概述
货号PTX20542
品牌ProteoGenix
描述
Anti-Human SETD7 Polyclonal Antibody (PTX20542) is a rabbit polyclonal antibody detecting Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human SETD7 (Met1-Lys366).
靶标Lysine N-methyltransferase 7, SET9, SET7/9, Histone H3-K4 methyltransferase SETD7, SET7, SET domain-containing protein 7, SETD7, H3-K4-HMTase SETD7, KIAA1717, Histone-lysine N-methyltransferase SETD7, KMT7
纯化方式Purified by antigen affinity column.
Accession号Q8WTS6
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Histone-lysine N-methyltransferase SETD7 is a ~40 kDa protein. Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.

1. Wang, H. et al. (2001) Molecular cell 8, 1207-17. PMID: 11779497
2. Nishioka, K. et al. (2002) Genes & development 16, 479-89. PMID: 11850410
3. Xiao, B. et al. (2003) Nature 421, 652-6. PMID: 12540855
4. Martens, JH. et al. (2003) Molecular and cellular biology 23, 1808-16. PMID: 12588998
5. Francis, J. et al. (2005) The Journal of biological chemistry 280, 36244-53. PMID: 16141209
9. Xiao, Y. et al. (2022) Bone research 10, 19. PMID: 35210392
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human SETD7 Polyclonal Antibody

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