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Anti-Human GATM Polyclonal Antibody (PTX19947)

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概述
货号PTX19947
品牌ProteoGenix
描述
Anti-Human GATM Polyclonal Antibody (PTX19947) is a rabbit polyclonal antibody detecting Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, GATM, Transamidinase, AGAT in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human GATM (Glu76-Asp423).
靶标Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, GATM, Transamidinase, AGAT
纯化方式Purified by antigen affinity column.
Accession号P50440
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Glycine amidinotransferase, mitochondrial (GATM) is a ~48 kDa protein. Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable).

1. Cullen, ME. et al. (2006) Circulation 114, I16-20. PMID: 16820567
2. DesRoches, CL. et al. (2016) Human mutation 37, 926-32. PMID: 27233232
3. Sinn, M. et al. (2022) Scientific reports 12, 22088. PMID: 36543883
4. Gross, MD. et al. (1986) Archives of biochemistry and biophysics 251, 747-55. PMID: 3800397
5. Fritsche, E. et al. (1997) European journal of biochemistry 247, 483-90. PMID: 9266688
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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